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The sweet oranges or Citrus sinensis (CS) fruit is a member of the family Rutaceae. It accounts for nearly 70% of the total annual production of the Citrus species. It is usually introduced in folk medicine to treat the common cold due to its high content of vitamin C that supports the immune system. The CS residues from orange juice industry are the peel and seeds that constitute about 50% of the juice industry wastes. Nevertheless, almost all the parts of the oranges can be consumed for industrial and medicinal uses. Citrus Sinensis peel (CSP) contains many nutrients and antinutrients. Nutrients in the aqueous and ethanol CSP extracts included carbohydrates, proteins, fixed oils, sugars, and amino acids. The antinutrients included saponins and tannins. Studies have documented the antioxidant properties of the CSP extract due to the phytochemical constituents, including flavonoids and phenolic compounds. These phytochemical properties encourage the usage of the CSP extract in the food industry and for medical purposes. The industrial uses of the CSP extracts involve food preservation due to their antimicrobial and antioxidant activities. The edible and industrial applications of the seed oil are among the documented uses of CS. The orange pomace powder has been found to increase the acceptability and the nutritional value of the cake when added in a percentage of 10% to the refined wheat. The residue of the CS has been identified as food supplements due to its high fiber and phenolics content. Moreover, the CS wastes are an excellent source for the production of biofuel and biodiesel. The wastes of CS represent an environmental burden. Hence, incorporating the CS residues in eco-friendly medical and industrial uses is of multiple benefits to the environment, the industry, and human health. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.
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Like all public utility, swimming pools had been treated with special procedures during the COVID19 pandemic. In addition to the basic rules (social distance + hand disinfection + masks), applicable to all citizens, the managers of swimming pools were obliged to reduce the number of swimmers and to increase the effects of water treatment. Monitoring, control and rapid response to unfavourable changes in the quality of swimming pool water are the basis for minimizing the risk of disease transmission or exposure of bathers to pathogens. The main purpose of this work is to analyse and compare the quality of swimming pool water in a municipal outdoor swimming pool complex, before (2018-2019) and during the COVID-19 pandemic (2020-2021). Water samples taken from a paddling pool for children (CP), a recreational pool (RP), and a sports pool (SP) were analysed. The results of the research, based on real case studies, were compared with the documents on water quality in swimming pools in force at the time. An analysis was carried out to determine the relationships between swimming pool water quality before and during the COVID-19 pandemic. The tested parameters determining the quality of water were physico-chemical parameters (temperature, pH, redox, and bacteriological parameters (colony forming units CFU of Pseudomonas aeruginosa, Escherichia coli, Legionella sp.). Based on the results of the analysis of the parameters mentioned-above, the validation of the procedures applied during the COVID-19 hazard and their impact on the quality of swimming pool water were evaluated. The results of the pool water quality tests were discussed with particular emphasis on disinfection by-products (THM and combined chlorine). Detailed analysis showed better water quality in the first year of the pandemic (2020) compared to 2018-2019 (before COVID-19) and 2021 (the second year of COVID-19 pandemic). The following parameters were found to be significantly different: THM (before 0.069 mg/L and during 0.034 mg/L), free chlorine (before 0.86 mg/L and during 0.66 mg/L), and redox potential (before 667 and during 713 mV).
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PurposeThe purpose of this paper was to determine the profile of dairy product consumers in the organic market.Design/methodology/approachThe study was based on a survey questionnaire developed by the author and administered to a total of 1,108 respondents. The statistical analysis (including descriptive statistics, the analysis of the discriminative function and the Chi2 test was performed with the use of Statistica 13.1 PL. The respondents' gender was the factor behind the differences in how they behaved.FindingsThe consumers indicated the channels they rely upon to find information on organic dairy products;in addition to trusting the opinions of their family members and experts, they also use web platforms. Further, they specified their preferred locations for buying favorite products during the pandemic: specialized organic food shops, large distribution chains and online stores.Practical implicationsThese outcomes will help in identifying target consumer segments and information channels for specific information and advertising messages. They also form an important resource for developing some potential strategies which the supply chain stakeholders could implement to promote organic consumption of dairy products.Originality/valueThis study identifies consumers' preferred dairy products;motives for purchasing organic dairy products;barriers that consumers believe exist in the market;sources of knowledge about products purchased by consumers;and consumers' preferred channels for purchasing organic dairy products. To the best of the author's knowledge, this is the first study of dairy product consumers in the organic market in Poland.
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Final Senate approval by a historically narrow 50-46 vote came only after the White House and Califf's supporters lobbied hard to gain sufficient support, a success that is very different from Califf's 89-4 approval back in 2016. Pressure to help control the high cost of prescription drugs will continue to drive FDA support for developing complex generic drugs and biosimilars. There is pressure to clarify rules governing e-cigarettes;a need to address serious health problems arising from contaminated food and seafood, including significant volumes of imported products;and the safety of cosmetic products, dietary supplements, sunscreens, and other non-prescription products raise additional complex issues.
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In spelling out the data expected for such authorization, agency officials emphasized the importance of fully vetting the safety and efficacy of any new coronovirus vaccine through a highly transparent process to boost public confidence in the ability of vaccines to save lives. Countering vaccine hesitancy Through the debate, officials in the Center for Biologics Evaluation and Research (CBER) emphasized that the EUA safety data requirement was already well known to vaccine manufacturers and that one aim was to assure manufacturers that FDA would hold all vaccine development programs to the same standards. Center for Biologics Evaluation and Research (CBER) Director Peter Marks further emphasized that the guidance sought to reassure the public that granting an EUA would not be a rushed decision on vaccine safety and efficacy to meet political goals, and that a vaccine EUA would require more data than for the more usual emergency authorizations for therapeutics and other medical products.
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The much-anticipated meeting of FDA's Vaccines and Related Biological Products Advisory Committee (VRBPAC) last month addressed a number of critical issues related to testing and approval of vaccines to prevent COVID-19 infection, including policies and data requirements for determining that a pandemic vaccine can be considered safe and effective, particularly when based on more limited, early clinical trial data. While studies sponsored by AstraZeneca and Johnson & Johnson's Janssen unit resumed soon after the meeting, the study pauses were described by researchers as a sign that clinical trial safety systems were working as intended, as the analysts determined the adverse events were unrelated to the test vaccine candidates. The aim is to gain further information on vaccine efficacy and side effects, including rare adverse events and fuller comparisons among patient groups with differences in age, sex, comorbidities, and ethnic characteristics.
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Vietnam is a country that produces a variety of agricultural products, including vegetables, tubers, fruits, and processed products. Along with the increase in population, the demand for consumers also increases, and the by-products of farming are increasing and being discharged into the environment. This is one of the critical research issues that need to be solved to ensure sustainability in agriculture. This review summarized recent studies on familiar sources of by-products in Vietnam, such as banana peels, citrus peels, dragon fruit skins, rice bran, and rice husks, and their potential in the food industry. Some solutions are also proposed to solve and turn this low-value raw material into a high-value product and serve a variety of products and consumers in the food industry. Especially after the COVID19 pandemic, the by-products contain valuable and reusable biological resources. These compounds could be future applications to support improving the consumer's immune system and various health benefits. Processed and utilized by-products from food production could not only help increase incomes for farmers, especially in developing countries like Vietnam but also could aid in ensuring food security and sustainability in agricultural production.
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BackgroundThe COVID-19 pandemic triggered serious challenges in the treatment of chronic diseases due to the lack of access to medical attention. Patients with rheumatic diseases (RD) must have adequate treatment compliance in order to reach and maintain remission or low activity of their diseases. Treatment suspension because of non-medical reasons might lead to disease activation and organ damage.ObjectivesIdentify the frequency of biologic treatment (bDMARD) suspension in patients with RD during the COVID-19 pandemic and determine the associated factors for suspension.MethodsIn this study we included all patients registered in the Mexican Biologics Adverse Events Registry (BIOBADAMEX), that started bDMARD before March 2019 and suspended treatment during the COVID-19 pandemic. We used descriptive statistic to analyze baseline characteristics and main treatment suspension causes. We used Chi[2] and Kruskal Wallis tests to analyze differences between groups.ResultsA total of 832 patients patients registered in BIOBADAMEX were included in this study, 143 (17%) suspended bDMARD during the COVID-19 pandemic. The main causes of suspension were inefficacy in 54 (38%) patients, followed by other motives in 49 (34%) patients from which 7 (5%) was loss of medical coverage. Adverse events and loss of patients to follow up were the motive in 16 (11%) and 15 (11%) patients respectively.When we compared the group that suspended bDMARD with the non-suspenders (Table 1), we found statistical differences in patient gender, with 125 (87%) female patients that suspended bDMARD, with a median age of 52 (42-60) years, and a treatment duration of 3.8 years.ConclusionIn our study we found that 17% of patients with RD suspended bDMARD treatment during the COVID-19 pandemic and that non-medical motives such as lack of patients follow up and loss of medical coverage due to unemployment were important motives. These results are related to the effect of the pandemic on other chronic diseases.Table 1.Patients baseline characteristicsPatients that did not suspended bDMARD during pandemic (n = 689)Patients that suspended bDMARD during pandemic (n = 143)pFemale gender, n(%)549 (79.7)125 (87.4)0.02Age, median (IQR)55 (45 – 63)52 (42 – 60)0.04Body mass index, median (IQR)26.4 (23 – 30.4)27.23 (24.2 – 30.46)0.13Social security, n(%)589 (85.5)128 (89.5)0.2Diagnosis0.7- Rheumatoid arthritis444 (64.4)97 (67.8)- Juvenil idiopathic athritis29 (4.2)2 (1.4)- Ankyosing sponylitis93 (13.5)19 (13.3)- Psoriasic arthritis43 (6.2)6 (4.2)- Systemic lupus erithematosus32 (4.6)9 (6.3)- Others48 (6.9)10 (6.9)Disease duration, median (IQR)11 (7 – 19.5)12 (6 - 18)0.95Comorbidities, n(%)305 (44.3)73 (51)0.08Previos biologic, n(%)249 (36.1)60 (42)0.1Treatment at pandemic iniciation, n(%)0.8 - Etanercept a34 (4.9)5 (3.5)- Infliximab a24 (3.5)5 (3.5)- Adalimumab130 (18.9)22 (15.4)- Rituximab a61 (8.9)25 (17.5)- Abatacept76 (11)20 (14)- Tocilizumab82 (11.9)18 (12.6)- Certolizumab92 (13.4)28 (19.6)- Rituximab b7 (1)0- Golimumab36 (5.2)5 (3.5)- Tofacitinib14 (2)1 (0.7)- Infliximab b4 (0.5)2 (1.4)- Etanercept b31 (4.5)6 (4.2)- Baricitinib12 (1.7)1 (0.7)- Belimumab5 (0.7)1 (0.7)- Secukinumb8 (1.2)3 (2.1)Steroids use, n(%):254 (36.9)57 (39.9)0.2Steroids dose (mg), median (IQR)6 (5 – 10)6 (5 – 10)0.47DMARD use, n(%):538 (78.1)118 (82.5)0.1Treatment duration, median (IQR)5.06 (4.04 – 5.78)3.82 (3.35 – 4.95)0.001Suspension motive, n(%)NA- Inefficacy-54 (37.8)- Adverse event-16 (11.2)- Pregnancy-2 (1.4)- Loss of patient-15 (10.5)- Remission-7 (4.9)- Others-49 (34.2)Adverse events, n(%):102 (14.8)24 (16.8)0.3- Severe, n(%)13 (1.9)5 (3.5)0.4a original, b biosimilarREFERENCES:NIL.Acknowledgements:NIL.Disclosure of InterestsVijaya Rivera Teran: None declared, Daniel Xavier Xibille Friedmann: None declared, David Vega-Morales: None declared, Sandra Sicsik: None declared, Angel Castillo Ortiz: None declared, Fedra Irazoque-Palazuelos: None declared, Dafhne Miranda: None declared, Iris Jazmin Colunga-Pedraza: None declared, Julio Cesar Casasola: None declared, Omar Elo Muñoz-Monroy: None declared, Sandra Carrilo: None declared, Angélica Peña: None declared, Sergio Duran Barragan: None declared, Luis Francisco Valdés Corona: None declared, Estefanía Torres Valdéz: None declared, Azucena Ramos: None declared, Aleni Paz: None declared, ERICK ADRIAN ZAMORA-TEHOZOL: None declared, Deshire Alpizar-Rodriguez Employee of: Scientific Advisor in GSK México.
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The various crises are having a significant impact on the entire food sector and are changing the attitudes of Europeans as well as policies on the importance of food security and sustainably produced quality and safe food for consumer health. The paper focuses on the consumer's fear of food security for the time of the first wave of COVID-19 and the associated concern for food security in the future and the changes in consumer behaviour. The online survey in Slovenia was conducted in June 2020 using a "snowball" method. The sample included 490 individuals. The results showed that both measured forms of fear (i) fear over food security during the first wave of COVID-19 crisis, and (ii) fear over food security in the future were statistically significant, moderately strong and positively associated with almost all forms of self-perceived behaviour change caused by the COVID-19 crisis. The respondents focused more on buying locally produced and processed food, food stockpiling and decreasing food waste. Only minor changes were expressed with regards to their food purchasing channels, with the elderly, the highly educated and those who classified themselves in a higher social class buying more often directly from farmers. In the future, the results of this research should be compared with other countries and the impact of an individual's economic situation and the impact of promotional campaigns on agricultural products on changing consumer behaviour should also be analysed in more detail.
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In December 2019, a novel coronavirus broke out in Wuhan City, Hubei Province, and, as the center of the coronavirus disease 2019 (COVID-19) epidemic, the economy and production throughout Hubei Province suffered huge temporary impacts. Based on the input–output and industrial pollution emissions data of 33 industrial industries in Hubei from 2010 to 2019, this article uses the non-parametric frontier analysis method to calculate the potential production losses and compliance costs caused by environmental regulations in Hubei's industrial sector by year and industry. Research has found that the environmental technology efficiency of the industrial sector in Hubei is showing a trend of increasing year-on-year, but the overall efficiency level is still not high, and there is great room for improvement. The calculation results with and without environmental regulatory constraints indicate that, generally, production losses and compliance costs may be encountered in the industrial sector in Hubei, and there are significant differences by industry. The potential production losses and compliance costs in pollution-intensive industries are higher than those in clean production industries. On this basis, we propose relevant policy recommendations to improve the technological efficiency of Hubei's industrial environment, in order to promote the high-quality development of Hubei's industry in the post-epidemic era.
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Broiler chicken eggs are one of the main and strategic foods for the people of Indonesia and contribute to regional and national inflation. Broiler egg production in Indonesia differs between regions. Areas with a surplus of eggs tend to have lower prices than areas with a deficit. This research is to measure the transmission of broiler egg prices between markets in surplus and deficit areas, using weekly price time series data for the period January 2018-December 2021. Areas of surplus broiler eggs, East Java Province (the highest broiler egg production in Indonesia) which become one of the main suppliers to the Province of East Nusa Tenggara as a deficit area. Using the Johannsen cointegration test it is found that there is no cointegration or there is no relationship between the surplus and deficit regions in the long term but not in the short term. Factors of marketing infrastructure, market information systems, and geographical conditions can be obstacles to the absence of cointegration. The VAR (Vector Auto-Regressive) Vector Error Correction model (VECM) test, found that price transmission occurred between surplus and deficit areas, meaning that between the two regions, there was market integration prior to Covid. The transmission has weakened, and due to the Covid situation, there have been restrictions on the movement of people and goods. The government and other market players need to study the response of the broiler egg market, in the short and long term so that market players can make the right policies.
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According to market research, the pharmaceutical packaging sector is expected to grow at a compound annual rate of 7.4% between 2022 and 2031, reaching an estimated USS178.8 billion (€171.8 billion) by the end of the forecast period (1). "Pharmaceutical waste continues to be a huge problem, so to eliminate non-biodegradable and single-use plastics from the supply chain, more research is taking place around bio-based PET [polyethylene terephthalate]. "By designing a product's primary and secondary packaging well from the outset (including investing ample resources into the process), manufacturers can reduce the amount of materials used and wasted, test new eco materials, ensure safety compliance and efficacy, and benefit from cheaper transportation costs," Quelch surmises. [...]pharma companies can benefit from a packaging supplier with a true global footprint," he says.
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According to Jens Kürten, group senior director, Communication and Marketing, Gerresheimer, there are nine megatrends that will both characterize and influence the pharmaceutical packaging market. Whether the drug be injected intravenously or subcutaneously, at home or in a hospital setting, there are various needs that should be considered prior to choosing the 'best-fit' packaging, he adds. [...]packaging requirements for pharmaceuticals change over time as the lifecycle of the drug continues," Stöcker states. [...]customers request more eco-friendly options to reduce or avoid plastic. [...]it has been necessary to design the packaging for the vaccines with these specific requirements in mind to ensure the safety and efficacy of the therapeutic product are protected.
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Nowadays, the social dimension of product sustainability is increasingly in demand, however, industrial designers struggle to pursue it much more than the environmental or economic one due to their unfamiliarity in correlating design choices with social impacts. In addition, this gap is not filled even by the supporting methods that have been conceived to only support specific areas of application. To fill this gap, this study proposed a method to support social failure mode and effect analysis (SFMEA), though the automatic failure determination, based on the use of a chatbot (i.e., an artificial intelligence (AI)-based chat). The method consists of 84 specific questions to ask the chatbot, resulting from the combination of known failures and social failures, elements from design theories, and syntactic structures. The starting hypothesis to be verified is that a GPT Chat (i.e., a common AI-based chat), properly queried, can provide all the main elements for the automatic compilation of a SFMEA (i.e., to determine the social failures). To do this, the proposed questions were tested in three case studies to extract all the failures and elements that express predefined SFMEA scenarios: a coffee cup provoking gender discrimination, a COVID mask denying a human right, and a thermometer undermining the cultural heritage of a community. The obtained results confirmed the starting hypothesis by showing the strengths and weaknesses of the obtained answers in relation to the following factors: the number and type of inputs (i.e., the failures) provided in the questions;the lexicon used in the question, favoring the use of technical terms derived from design theories and social sustainability taxonomies;the type of the problem. Through this test, the proposed method proved its ability to support the social sustainable design of different products and in different ways. However, a dutiful recommendation instead concerns the tool (i.e., the chatbot) due to its filters that limit some answers in which the designer tries to voluntarily hypothesize failures to explore their social consequences.
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COVID-19 vaccines, approved under emergency use authorization, were not required to meet serialization requirements, but they have been properly labelled to meet US Food and Drug Administration (FDA) requirements, he says, complete with 2D barcodes with GTIN, lot, and expiry date. The company decided to serialize its Diprovan anesthetic, a workhorse generic product, using radio frequency identification tags containing the four identifiers (2). "If an agent is handling your product on your behalf, they need to leverage GS1 Standards including GTINs for products [and] global location numbers (GLNs) for physical locations, and share data electronically using electronic product code information services (EPCIS) to capture events from manufacturing to serialization [and] capping to shipping.
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The People's Republic of China has the largest population in the world, making it both one of the most fascinating and rapidly expanding import markets for food and beverages as well as one of the most difficult. The Chinese market is appealing to foreign food producers because of the country's high per capita income and quick urbanization. The Agriculture Chapter addressed fundamental trade barriers and will support a significant increase in the export of food, agricultural, and seafood products from the United States, boosting farm and fishery revenue, stimulating rural economies, and fostering employment growth. Numerous non-tariff barriers to the export of U.S. agricultural and seafood products are discussed, including those relating to rice, dairy, infant formula, horticulture products, animal feed and feed additives, pet food, and agricultural biotechnology products, as well as meat, chicken, and seafood. The U.S. has achieved significant export successes thus far, despite the pandemic. Decrees 248 and 249, which take effect on January 1, 2022, mandate that foreign suppliers of particular food products to China register with the GACC before presenting their goods for customs clearance. Several Global Agricultural Information Network (GAIN) reports on GACC Decrees 248 and 249 have been published by FAS offices in China. For the most recent information on whether their business has to register, whether it can self-register, or if it needs to be recommended for registration by a U.S. competent body, U.S. exporters should examine the GAIN system, which offers points of contact at the GACC. According to Euromonitor, urban Chinese customers who are short on time choose shopping near residential areas, especially in the wake of the COVID-19 outbreak. During the crisis, consumers grew accustomed to shopping in their immediate areas. As a result, many major modern grocery chains have used a multi-format strategy and constructed smaller-format stores. Freshippo, Yonghui, and Carrefour are all opening smaller, more neighborhood-focused stores that place an increased emphasis on fresh foods. Some of these shops also act as e-commerce order warehouses and offer prompt home deliveries. Particularly Yonghui has opened Yonghui Mini Stores quickly as an addition to its hypermarket and major supermarket operations. The food processing sector in China has been expanding steadily in recent years. According to the Chinese Ministry of Industry and Information Technology (MIIT), sales, production, and income in the sector rose in 2020. The total profits of China's largest food processing firms reached 620.66 billion yuan (about US$97 billion) in 2020, an increase of 6.8% over the same period in 2019. According to MIIT, these businesses' profit growth was 3.1% higher than the average for all industrial sectors.
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The COVID-19 Pandemic led to a strong increase in demand for medical products. At the same time, supply problems in international supply chains kicked in due to health policy interventions (e.g., lockdowns) and economic policy measures (e.g., export controls). Combined, both resulted in temporary shortages and triggered a controversial discussion about the advantages and disadvantages of globalised production structures, which led to strong dependencies on a few, primarily Asian, locations and producers. Against this background and based on case studies for Austria, the article deals with the question which factors determine the robustness of global commodity chains for respirators, protective gloves and respiratory equipment and which national and European policies could be suitable for increasing resilience in the supply of medical products. © 2022 Austrian Geographical Society. All rights reserved.
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Background: The Food Commerce industry has flourished massively during the past decade in South Kolkata in West Bengal, with new outlets opening every now and then, so much so that this region is known as 'Food Street'. Regardless of their scale of operations, each of these outlets had well established themselves, catering to their respective target markets and earning decent amount of revenue over the years. However, this growth suffered a setback owing to the origin of novel Coronavirus SARS-n-CoV-2. The growth rate declined to a great extent over the span of two years, with recent studies showing an overall stunted growth rate. Even though online marketing of these outlets and selling the food through delivery apps have aided the entrepreneurs, the cost to revenue ratio is not at par with that of the times before the pandemic hit. Overall, the pandemic has impacted the eateries in more way than initially imagined. Objectives: (a) To reveal the various problems and scenarios of managing food business during the Covid-19 pandemic in South Kolkata region;(b) To compare the present scenario of the food industry with how things were before prior to the pandemic to understand the nature of change during this time frame;and, (c) To describe the challenges and methods implemented by the food retail business entrepreneurs and managers of the randomly selected establishments to hold a steady business flow during the Covid-19 pandemic. Methodology: The study follows a descriptive research design. Therefore, the research will describe the characteristics of the sample under study. The food outlets of South Kolkata have been chosen as the study location. 100 respondents were selected. The respondents are those who consume food from these outlets such that they represent the wider target market of the 'Food Street'. Both Primary Data and Secondary Data were used. Primary Data was collected through sample survey. Random Sampling technique was used to choose the respondents. The study used quantitative data, therefore, only Quantitative analysis was performed. Results: The Research was able to depict the comparison between the present scenario and the situation prior to the pandemic. The study was able to reveal the challenges and problems that the food outlets had to suffer from. Also, the methods or strategies taken up by the entrepreneurs of these outlets to overcome the pandemic were discovered. 46% of the respondents opted for "Mobile Food Delivery" as their strategy to revive from losses. Conclusion: With COVID-19 having altered - and still in the process of altering - the definition of "normal" across the world, most industries are still scrambling to adjust. The effect on the restaurant industry has been particularly dramatic. With restaurants and pubs closed for sit-down service, many establishments are struggling to keep their heads above water. The food outlets located in South Kolkata shares the same fate and the research is able to highlight this effectively.
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According to Jeetendra Vaghjiani, senior director of clinical development and strategic marketing at Lonza, emerging biotech companies are reliant on contract development and manufacturing organizations (CDMOs) because of their development and manufacturing capacity, expertise, and flexibility. Because of the high attrition rate associated with drug development, the better your preclinical programme, the stronger the position you can establish in terms of programme design and patient identification (2). [...]because of the relative scarcity of approvals over the past decade, companies looking to capitalize on this new market are likely to require specialized knowledge to get through the approvals process.
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[...]on 25 Nov. 2020, the European Commission (EC) announced the new Pharmaceutical Strategy for Europe, which is likely to result in significant changes to the European Union (EU) regulatory framework and will have a substantial impact on both the marketing of medicinal products and the strategic business planning of pharmaceutical companies (2). (2021), the priority areas are as follows: * The performance and adequacy of the current legislation * Unmet medical needs-with a definition or set of principles for "unmet medical needs" under discussion * Incentives for innovation, including the area of unmet needs and a reflexion on regulatory data and market exclusivity * Antimicrobial resistance that includes measures to support innovation of antibiotic development * Future-proofing the regulatory framework for novel products * Improved patient access to, and affordability of, medicines in the EU * Competitiveness of the European markets to ensure affordable medicines, including considering measures to support patients' access to affordable medicines * Encouraging the repurposing of off patent medicines * Ensuring security of supply of medicinal products in the EU * Ensuring high-quality manufacture and distribution in the EU including consideration of the need to strengthen or adapt good manufacturing practice (GMP) to reflect new manufacturing methodologies * Environmental challenges (4). Availability, accessibility, and affordability of medicinal products The section on 'Prioritising unmet medical needs' in the strategy reflects the belief within EU Bianca Piachaud-Moustakis is lead writer at PharmaVision, Pharmavision.co.uk. institutions that "current incentive models neither provide an adequate solution for unmet medical needs nor appropriately incentivise investments in innovation" (2).